Endocrine Abstracts

Extracellular matrix protein 1 (ECM1) is an 85 kDa glycoprotein that plays an important role in skin physiology, angiogenesis, tumor progression and malignancies. However, the function of ECM-1 in regulation of the immune responses has not been identified. Recent studies showed ECM-1 deficiency lowers the capacity of T helper 2 (Th2) cells to emigrate from draining lymph nodes to an inflamatory site. Lipoid proteinosis (LiP) and Licken Sclerosus (LS) are immunogenetic counterp...